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Issue 32, 2019
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An enzymatic Finkelstein reaction: fluorinase catalyses direct halogen exchange

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Abstract

The fluorinase enzyme from Streptomyces cattleya is shown to catalyse a direct displacement of bromide and iodide by fluoride ion from 5′-bromodeoxyadenosine (5′-BrDA) and 5′-iododeoxyadenosine (5′-IDA) respectively to form 5′-fluorodeoxyadenosine (5′-FDA) in the absence of L-methionine (L-Met) or S-adenosyl-L-methionine (SAM). 5′-BrDA is the most efficient substrate for this enzyme catalysed Finkelstein reaction.

Graphical abstract: An enzymatic Finkelstein reaction: fluorinase catalyses direct halogen exchange

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Supplementary files

Article information


Submitted
27 Jun 2019
Accepted
25 Jul 2019
First published
25 Jul 2019

Org. Biomol. Chem., 2019,17, 7493-7496
Article type
Paper

An enzymatic Finkelstein reaction: fluorinase catalyses direct halogen exchange

P. T. Lowe, S. L. Cobb and D. O'Hagan, Org. Biomol. Chem., 2019, 17, 7493
DOI: 10.1039/C9OB01625B

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