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Issue 36, 2019
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Benzannulated spiroketal natural products: isolation, biological activity, biosynthesis, and total synthesis

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Abstract

The spiroketal moiety is an important privileged scaffold that occurs extensively in natural products, drugs, and bioactive molecules. Naturally occurring spiroketals are numerous, however aryl-fused spiroketals are relatively rare. The only comprehensive review disclosing the isolation, biological activity, and synthesis of benzannulated spiroketal natural products was published nearly a decade ago. This review will serve as an update of the 2009 review and include all known families of benzannulated spiroketals, detailing their isolation and biological activity where relevant. Although not exhaustive, endeavours towards their total synthesis will be discussed.

Graphical abstract: Benzannulated spiroketal natural products: isolation, biological activity, biosynthesis, and total synthesis

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Publication details

The article was received on 19 Jul 2019, accepted on 21 Aug 2019 and first published on 21 Aug 2019


Article type: Review Article
DOI: 10.1039/C9OB01598A
Org. Biomol. Chem., 2019,17, 8272-8307

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    Benzannulated spiroketal natural products: isolation, biological activity, biosynthesis, and total synthesis

    R. M. Gillard and M. A. Brimble, Org. Biomol. Chem., 2019, 17, 8272
    DOI: 10.1039/C9OB01598A

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