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Issue 31, 2019
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Transition metal-free α-methylation of 1,8-naphthyridine derivatives using DMSO as methylation reagent

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Abstract

A practical approach to the direct α-methylation of 1,8-naphthyridines under mild reaction conditions has been developed using simple and readily available DMSO as a convenient and environmentally friendly carbon source. This method is transition metal-free and highly chemoselective, shows good functional group tolerance, and uses DMSO as a methyl source, providing efficient and rapid access to an important compound class, 2-methyl-1,8-naphthyridines.

Graphical abstract: Transition metal-free α-methylation of 1,8-naphthyridine derivatives using DMSO as methylation reagent

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Publication details

The article was received on 03 Jul 2019, accepted on 24 Jul 2019 and first published on 25 Jul 2019


Article type: Paper
DOI: 10.1039/C9OB01490J
Org. Biomol. Chem., 2019,17, 7416-7424

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    Transition metal-free α-methylation of 1,8-naphthyridine derivatives using DMSO as methylation reagent

    S. Jiang, Z. Yang, Z. Guo, Y. Li, L. Chen, Z. Zhu and X. Chen, Org. Biomol. Chem., 2019, 17, 7416
    DOI: 10.1039/C9OB01490J

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