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Issue 31, 2019
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Chemoenzymatic synthesis of the oligosaccharide moiety of the tumor-associated antigen disialosyl globopentaosylceramide

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Abstract

Disialosyl globopentaosylceramide (DSGb5) is often expressed by renal cell carcinomas. To investigate properties of DSGb5, we have prepared its oligosaccharide moiety by chemically synthesizing Gb5 which was enzymatically sialylated using the mammalian sialyltransferases ST3Gal1 and ST6GalNAc5. Glycan microarray binding studies indicate that Siglec-7 does not recognize DSGb5, and preferentially binds Neu5Acα(2,8)Neu5Ac containing glycans.

Graphical abstract: Chemoenzymatic synthesis of the oligosaccharide moiety of the tumor-associated antigen disialosyl globopentaosylceramide

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Article information


Submitted
17 Jun 2019
Accepted
18 Jul 2019
First published
18 Jul 2019

Org. Biomol. Chem., 2019,17, 7304-7308
Article type
Communication

Chemoenzymatic synthesis of the oligosaccharide moiety of the tumor-associated antigen disialosyl globopentaosylceramide

I. M. E. 't Hart, T. Li, M. A. Wolfert, S. Wang, K. W. Moremen and G. Boons, Org. Biomol. Chem., 2019, 17, 7304
DOI: 10.1039/C9OB01368G

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