Silver-promoted decarboxylative radical addition/annulation of oxamic acids with gem-difluoroolefins: concise access to CF2-containing 3,4-dihydroquinolin-2-ones

Guojun Chen; Chenglong Li; Jianfeng Peng; Zeli Yuan; Peijun Liu; Xiaozu Liu

doi:10.1039/C9OB01236B

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

Silver-promoted decarboxylative radical addition/annulation of oxamic acids with gem-difluoroolefins: concise access to CF₂-containing 3,4-dihydroquinolin-2-ones†

Guojun Chen,^a Chenglong Li,^a Jianfeng Peng,^a Zeli Yuan,^a Peijun Liu

*^a and Xiaozu Liu*^a

Author affiliations

* Corresponding authors

^a Key Laboratory of Biocatalysis & Chiral Drug Synthesis of Guizhou Province, Generic Drug Research Center of Guizhou Province, School of Pharmacy, Zunyi Medical University, Zunyi 563006, P. R. China
E-mail: lxz307@126.com, pjliu@zmc.edu.cn

Abstract

Described is a silver-promoted decarboxylative radical addition/annulation of oxamic acids with gem-difluoroalkenes. This reaction proceeded under mild reaction conditions with broad functional group compatibility, enabling the convenient synthesis of various structurally diverse CF₂-containing 3,4-dihydroquinolin-2-ones that might find applications in medical chemistry.

This article is part of the themed collections: Synthetic methodology in OBC and Catalysis & biocatalysis in OBC

Download options Please wait...

Supplementary files

Article information

DOI: https://doi.org/10.1039/C9OB01236B
Article type: Communication
Submitted: 28 May 2019
Accepted: 04 Sep 2019
First published: 05 Sep 2019

Download Citation

Org. Biomol. Chem., 2019,17, 8527-8532

Permissions

Request permissions

Silver-promoted decarboxylative radical addition/annulation of oxamic acids with gem-difluoroolefins: concise access to CF₂-containing 3,4-dihydroquinolin-2-ones

G. Chen, C. Li, J. Peng, Z. Yuan, P. Liu and X. Liu, Org. Biomol. Chem., 2019, 17, 8527 DOI: 10.1039/C9OB01236B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Social activity

Fetching data from CrossRef.
This may take some time to load.

Organic & Biomolecular Chemistry