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Issue 28, 2019
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A chemical approach for the synthesis of the DNA-binding domain of the oncoprotein MYC

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Abstract

We describe the first chemical synthesis of a functional mutant of the DNA binding domain of the oncoprotein MYC, using two alternative strategies which involve either one or two Native Chemical Ligations (NCLs). Both routes allowed the efficient synthesis of a miniprotein which is capable of heterodimerizing with MAX, and replicate the DNA binding of the native protein. The versatility of the reported synthetic approach enabled the straightforward preparation of MYC and Omomyc analogues, as well as fluorescently labeled derivatives.

Graphical abstract: A chemical approach for the synthesis of the DNA-binding domain of the oncoprotein MYC

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Publication details

The article was received on 23 May 2019, accepted on 29 May 2019 and first published on 29 May 2019


Article type: Communication
DOI: 10.1039/C9OB01209E
Org. Biomol. Chem., 2019,17, 6748-6752

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    A chemical approach for the synthesis of the DNA-binding domain of the oncoprotein MYC

    R. Calo-Lapido, C. Penas, A. Jiménez-Balsa, M. E. Vázquez and J. L. Mascareñas, Org. Biomol. Chem., 2019, 17, 6748
    DOI: 10.1039/C9OB01209E

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