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Issue 31, 2019
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Bimetallic Cu/Pd-catalyzed three-component azide–alkyne cycloaddition/isocyanide insertion: synthesis of fully decorated tricyclic triazoles

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Abstract

The construction of fully decorated 1,2,3-triazole-fused 5-, 6- and 7-membered rings has been disclosed via a bimetallic relay-catalyzed cascade process combining azide–alkyne cycloaddition, C(sp2)–H functionalization of intermediary 1,2,3-triazoles and isocyanide insertion. The salient features of this methodology include simple starting materials, reduced synthetic steps, good substrate scope and high efficiency.

Graphical abstract: Bimetallic Cu/Pd-catalyzed three-component azide–alkyne cycloaddition/isocyanide insertion: synthesis of fully decorated tricyclic triazoles

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Publication details

The article was received on 19 May 2019, accepted on 16 Jul 2019 and first published on 16 Jul 2019


Article type: Communication
DOI: 10.1039/C9OB01175G
Org. Biomol. Chem., 2019,17, 7320-7324

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    Bimetallic Cu/Pd-catalyzed three-component azide–alkyne cycloaddition/isocyanide insertion: synthesis of fully decorated tricyclic triazoles

    K. Shiva Kumar, P. K. Naikawadi, R. Jatoth and R. Dandela, Org. Biomol. Chem., 2019, 17, 7320
    DOI: 10.1039/C9OB01175G

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