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Issue 25, 2019
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A simple route towards the synthesis of 1,4,5-trisubstituted 1,2,3-triazoles from primary amines and 1,3-dicarbonyl compounds under metal-free conditions

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Abstract

An acetic acid-promoted approach that enables the synthesis of 1,4,5-trisubstituted 1,2,3-triazole derivatives has been achieved. This transformation employs readily available primary amines, 1,3-dicarbonyls and tosyl azide as the starting materials via a cycloaddition reaction under metal-free conditions. The reaction provides a simple access to fully substituted 1,2,3-triazoles from commercial substrates in moderate to excellent yields.

Graphical abstract: A simple route towards the synthesis of 1,4,5-trisubstituted 1,2,3-triazoles from primary amines and 1,3-dicarbonyl compounds under metal-free conditions

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Article information


Submitted
17 May 2019
Accepted
05 Jun 2019
First published
06 Jun 2019

Org. Biomol. Chem., 2019,17, 6148-6152
Article type
Communication

A simple route towards the synthesis of 1,4,5-trisubstituted 1,2,3-triazoles from primary amines and 1,3-dicarbonyl compounds under metal-free conditions

N. Guo, X. Liu, H. Xu, X. Zhou and H. Zhao, Org. Biomol. Chem., 2019, 17, 6148
DOI: 10.1039/C9OB01156K

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