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Issue 35, 2019
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A hydroxamic-acid-containing nucleoside inhibits DNA repair nuclease SNM1A

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Abstract

Nine modified nucleosides, incorporating zinc-binding pharmacophores, have been synthesised and evaluated as inhibitors of the DNA repair nuclease SNM1A. The series included oxyamides, hydroxamic acids, hydroxamates, a hydrazide, a squarate ester and a squaramide. A hydroxamic acid-derived nucleoside inhibited the enzyme, offering a novel approach for potential therapeutic development through the use of rationally designed nucleoside derived inhibitors.

Graphical abstract: A hydroxamic-acid-containing nucleoside inhibits DNA repair nuclease SNM1A

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Publication details

The article was received on 15 May 2019, accepted on 12 Jun 2019 and first published on 05 Aug 2019


Article type: Paper
DOI: 10.1039/C9OB01133A
Org. Biomol. Chem., 2019,17, 8094-8105
  • Open access: Creative Commons BY license
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    A hydroxamic-acid-containing nucleoside inhibits DNA repair nuclease SNM1A

    W. Doherty, E. Dürr, H. T. Baddock, S. Y. Lee, P. J. McHugh, T. Brown, M. O. Senge, E. M. Scanlan and J. F. McGouran, Org. Biomol. Chem., 2019, 17, 8094
    DOI: 10.1039/C9OB01133A

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