Issue 28, 2019
From the journal:

Organic & Biomolecular Chemistry

The disruption of verM activates the production of gliocladiosin A and B in Clonostachys rogersoniana†

Ying Wang,‡ac   Jinwei Ren,‡ad   Honghua Li,ad   Yuanyuan Pan,a   Xingzhong Liu,a   Yongsheng Che ORCID logo *b  and  Gang Liu ORCID logo *ade  

* Corresponding authors

a State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China
E-mail: liug@im.ac.cn

b Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China
E-mail: cheys@im.ac.cn

c Beijing Shunxin Agriculture Co. Ltd, Niulanshan Distillery, Beijing, China

d University of Chinese Academy of Sciences, Beijing, China

e The Innovative Academy of Seed Design, Chinese Academy of Sciences, Beijing 100864, China

Abstract

Gliocladiosin A (1) and B (2), two dipeptides conjugated with macrolides, were identified from a verM disruption mutant of the Cordycep-colonizing fungus Clonostachys rogersoniana. The structures and absolute configurations of 1 and 2 were determined on the basis of spectroscopic data analysis, including MS, NMR, CD and X-ray diffraction. A biogenetic pathway for 1 and 2 was proposed. These two compounds showed moderate antibacterial effects.

Graphical abstract: The disruption of verM activates the production of gliocladiosin A and B in Clonostachys rogersoniana

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C9OB01102A
Article type
Communication
Submitted
13 May 2019
Accepted
27 Jun 2019
First published
28 Jun 2019

Org. Biomol. Chem., 2019,17, 6782-6785

Permissions

Request permissions

The disruption of verM activates the production of gliocladiosin A and B in Clonostachys rogersoniana

Y. Wang, J. Ren, H. Li, Y. Pan, X. Liu, Y. Che and G. Liu, Org. Biomol. Chem., 2019, 17, 6782 DOI: 10.1039/C9OB01102A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements