Combining enzymes and organometallic complexes: novel artificial metalloenzymes and hybrid systems for C–H activation chemistry
This review describes the recent advances in the design of novel artificial metalloenzymes and their application in C–H activation reactions. The combination of enzymes and metal or organometallic complexes for the creation of new artificial metalloenzymes has represented a very exciting research line. In particular, the development of proteins with the ability to perform C–H functionalization presents a significant challenge. Here we discuss the development of these processes on natural metalloenzymes by using directed evolution, biotin-(strept)avidin technologies, photocatalytic hybrids or reconstitution of heme-protein technology.
- This article is part of the themed collections: Catalysis & biocatalysis in OBC and Direct C-H Functionalization in Method Development and Late Stage Functionalization