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Issue 25, 2019
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Synthesis of β-sulfinyl cyclobutane carboxylic amides via a formal α to β sulphoxide migration process

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Abstract

An original tandem reaction consisting of a thermal elimination–addition process was developed. Highly substituted β-sulfinyl cyclobutane carboxylic acid derivatives were obtained from isomeric α-sulfinyl derivatives in a single operation in good to high yields and with high trans diastereoselectivity.

Graphical abstract: Synthesis of β-sulfinyl cyclobutane carboxylic amides via a formal α to β sulphoxide migration process

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Publication details

The article was received on 02 Apr 2019, accepted on 03 Jun 2019 and first published on 03 Jun 2019


Article type: Communication
DOI: 10.1039/C9OB00758J
Org. Biomol. Chem., 2019,17, 6143-6147

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    Synthesis of β-sulfinyl cyclobutane carboxylic amides via a formal α to β sulphoxide migration process

    L. Ghisu, N. Melis, L. Serusi, A. Luridiana, F. Soddu, F. Secci, P. Caboni, R. Guillot, D. J. Aitken and A. Frongia, Org. Biomol. Chem., 2019, 17, 6143
    DOI: 10.1039/C9OB00758J

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