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Issue 18, 2019
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Decarboxylative acylation of N-free indoles enabled by a catalytic amount of copper catalyst and liquid-assisted grinding

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Abstract

A facile decarboxylative acylation of N-free indoles with α-ketonates via liquid-assisted grinding was reported. The reaction requires only a catalytic amount of Cu(OAc)2·H2O in combination with O2 as the terminal oxidant to give various 3-acylindoles with high efficiency. Additionally, this new methodology was applicable to a gram-scale synthesis.

Graphical abstract: Decarboxylative acylation of N-free indoles enabled by a catalytic amount of copper catalyst and liquid-assisted grinding

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Publication details

The article was received on 16 Mar 2019, accepted on 05 Apr 2019 and first published on 06 Apr 2019


Article type: Communication
DOI: 10.1039/C9OB00622B
Org. Biomol. Chem., 2019,17, 4446-4451

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    Decarboxylative acylation of N-free indoles enabled by a catalytic amount of copper catalyst and liquid-assisted grinding

    J. Yu, C. Zhang, X. Yang and W. Su, Org. Biomol. Chem., 2019, 17, 4446
    DOI: 10.1039/C9OB00622B

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