SCHEDULED MAINTENANCE
A highly selective H/D exchange reaction of 1,4-dihydropyridines†
Ping
Wang 
*b
and
Feng
Liang
*a
*b
and
Feng
Liang
*a
Abstract
Herein, we report a simple, economical, and effective acid-mediated method for the in situ deuteration of Hantzsch esters and their 4-substituted derivatives, including some drugs that constitute important calcium channel blockers which are effective for hypertension treatment. Hydrogen isotope exchange occurred selectively at α-alkyl C–H bonds in the 2,6-substituents.
- This article is part of the themed collection: Synthetic methodology in OBC
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