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Issue 11, 2019
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Thiosquaramide-catalysed asymmetric double Michael addition of 2-(3H)-furanones to nitroolefines

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Abstract

New chiral thiosquaramides and their applications in catalytic asymmetric double addition of 5-methyl-2(3H)-furanones to nitroolefins were described. Enantiomerically enriched 2,4,4-trisubstituted butenolides bearing a quaternary stereogenic center could be smoothly constructed with high diastereoselectivities (up to >99 : 1 dr) and excellent enantioselectivities (up to 95% ee) under mild conditions.

Graphical abstract: Thiosquaramide-catalysed asymmetric double Michael addition of 2-(3H)-furanones to nitroolefines

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Publication details

The article was received on 10 Feb 2019, accepted on 15 Feb 2019 and first published on 16 Feb 2019


Article type: Communication
DOI: 10.1039/C9OB00330D
Org. Biomol. Chem., 2019,17, 2883-2886

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    Thiosquaramide-catalysed asymmetric double Michael addition of 2-(3H)-furanones to nitroolefines

    M. Yang, C. Chen, X. Yi, Y. Li, X. Wu, Q. Li and S. Ban, Org. Biomol. Chem., 2019, 17, 2883
    DOI: 10.1039/C9OB00330D

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