Jump to main content
Jump to site search

Issue 10, 2019
Previous Article Next Article

Glycoconjugate synthesis using chemoselective ligation

Author affiliations


Chemoselective ligation of carbohydrates and polypeptides was achieved using an adipic acid dihydrazide cross-linker. The reducing end of a carbohydrate is efficiently attached to peptides in two steps, constructing a glycoconjugate in high yield and with high regioselectivity, enabling the production of homogeneous glycoconjugates.

Graphical abstract: Glycoconjugate synthesis using chemoselective ligation

Back to tab navigation

Supplementary files

Publication details

The article was received on 01 Feb 2019, accepted on 12 Feb 2019 and first published on 12 Feb 2019

Article type: Communication
DOI: 10.1039/C9OB00270G
Org. Biomol. Chem., 2019,17, 2646-2650

  •   Request permissions

    Glycoconjugate synthesis using chemoselective ligation

    S. Cheng, P. L. Wantuch, M. E. Kizer, D. R. Middleton, R. Wang, M. DiBello, M. Li, X. Wang, X. Li, V. Ramachandiran, F. Y. Avci, F. Zhang, X. Zhang and R. J. Linhardt, Org. Biomol. Chem., 2019, 17, 2646
    DOI: 10.1039/C9OB00270G

Search articles by author