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Issue 12, 2019
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Lewis base catalyzed regioselective cyclization of allene ketones or α-methyl allene ketones with unsaturated pyrazolones

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Abstract

A nitrogen-containing Lewis base catalyzed highly regioselective [4 + 2] cycloaddition of allene ketones or α-methyl allene ketones with unsaturated pyrazolones has been disclosed to give the corresponding tetrahydropyrano [2,3-c] pyrazoles in moderate to good yields under mild conditions. High regioselectivity, 100% atom-economy, broad substrate scope and good functional group tolerance are attractive features of this process and make it a practical and versatile transformation.

Graphical abstract: Lewis base catalyzed regioselective cyclization of allene ketones or α-methyl allene ketones with unsaturated pyrazolones

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Supplementary files

Article information


Submitted
23 Jan 2019
Accepted
26 Feb 2019
First published
26 Feb 2019

Org. Biomol. Chem., 2019,17, 3232-3238
Article type
Paper

Lewis base catalyzed regioselective cyclization of allene ketones or α-methyl allene ketones with unsaturated pyrazolones

C. Cheng, X. Sun, Z. Wu, Q. Liu, L. Xiong and Z. Miao, Org. Biomol. Chem., 2019, 17, 3232
DOI: 10.1039/C9OB00179D

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