Issue 12, 2019
From the journal:

Organic & Biomolecular Chemistry

Asymmetric total synthesis of (+)-asenapine†

Piotr Szcześniak, ORCID logo *a   Olga Staszewska-Krajewskab  and  Jacek Mlynarski ORCID logo b  

* Corresponding authors

a Faculty of Chemistry, Jagiellonian University, Gronostajowa 2, 30-387 Kraków, Poland
E-mail: alchemik_84@tlen.pl

b Institute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, 01-224 Warsaw, Poland

Abstract

Asymmetric total synthesis of (+)-asenapine, an atypical antipsychotic drug, used for treating schizophrenia and acute mania associated with bipolar disorder, is reported. The key steps are the organocatalytic Michael addition of aldehydes to trans-nitroalkenes and subsequent reductive cyclization.

Graphical abstract: Asymmetric total synthesis of (+)-asenapine

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Article information

DOI
https://doi.org/10.1039/C9OB00178F
Article type
Paper
Submitted
23 Jan 2019
Accepted
26 Feb 2019
First published
26 Feb 2019

Org. Biomol. Chem., 2019,17, 3225-3231

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Asymmetric total synthesis of (+)-asenapine

P. Szcześniak, O. Staszewska-Krajewska and J. Mlynarski, Org. Biomol. Chem., 2019, 17, 3225 DOI: 10.1039/C9OB00178F

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