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Issue 8, 2019
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A hydrate salt-promoted reductive coupling reaction of nitrodienes with unactivated alkenes

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Abstract

Transition metal-catalyzed reductive coupling has emerged as a powerful method for the construction of C–C bonds. Herein, a crystalline hydrate, Na2HPO4·7H2O, has been disclosed as an effective promoter for the reductive coupling of nitrodienes with unactivated alkenes to afford diverse dienes with various functionalities in an open-flask manner. The mechanism study has revealed that Na2HPO4·7H2O accelerates the in situ generation of active silane PhSi(OEt)H2 and prevents the deactivation of catalyst. The approach can increase the efficiency of previous reductive coupling reactions as well.

Graphical abstract: A hydrate salt-promoted reductive coupling reaction of nitrodienes with unactivated alkenes

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Publication details

The article was received on 18 Jan 2019, accepted on 30 Jan 2019 and first published on 31 Jan 2019


Article type: Paper
DOI: 10.1039/C9OB00136K
Citation: Org. Biomol. Chem., 2019,17, 2258-2264

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    A hydrate salt-promoted reductive coupling reaction of nitrodienes with unactivated alkenes

    M. Zhang, L. Yang, C. Tian, M. Zhou, G. An and G. Li, Org. Biomol. Chem., 2019, 17, 2258
    DOI: 10.1039/C9OB00136K

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