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Issue 11, 2019
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Synthesis of trisaccharide repeating unit of fucosylated chondroitin sulfate

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Abstract

We described the chemical synthesis of a sulfated trisaccharide repeating unit of fucosylated chondroitin sulfate (FCS), which has significant anticoagulant activity. Well-functionalized monosaccharides were readily prepared, and highly efficient glycosylations using a common activator (NIS/TfOH) were also presented. The synthesized trisaccharide 4 could be used to extend oligosaccharide sequences.

Graphical abstract: Synthesis of trisaccharide repeating unit of fucosylated chondroitin sulfate

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Publication details

The article was received on 09 Jan 2019, accepted on 30 Jan 2019 and first published on 31 Jan 2019


Article type: Communication
DOI: 10.1039/C9OB00057G
Org. Biomol. Chem., 2019,17, 2877-2882

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    Synthesis of trisaccharide repeating unit of fucosylated chondroitin sulfate

    H. He, D. Chen, X. Li, C. Li, J. Zhao and H. Qin, Org. Biomol. Chem., 2019, 17, 2877
    DOI: 10.1039/C9OB00057G

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