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Issue 18, 2019
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An NHC-catalyzed, stereoselective α-functionalization of α,β-unsaturated carboxylic acids through in situ activation

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Abstract

An N-heterocyclic carbene (NHC)-catalyzed α-functionalization of the in situ activated α,β-unsaturated carboxylic acids bearing γ-H was realized through formal [4 + 2] annulations with o-quinone methides, which paved a new avenue for the assembly and modification of the dihydrocoumarin scaffold in good yields with excellent diastereo- and enantioselectivities.

Graphical abstract: An NHC-catalyzed, stereoselective α-functionalization of α,β-unsaturated carboxylic acids through in situ activation

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Publication details

The article was received on 26 Dec 2018, accepted on 09 Apr 2019 and first published on 10 Apr 2019


Article type: Paper
DOI: 10.1039/C8OB03206H
Org. Biomol. Chem., 2019,17, 4564-4571

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    An NHC-catalyzed, stereoselective α-functionalization of α,β-unsaturated carboxylic acids through in situ activation

    Z. Wang, H. Zhang, H. Qian, Y. Wang, C. Yu, T. Li and C. Yao, Org. Biomol. Chem., 2019, 17, 4564
    DOI: 10.1039/C8OB03206H

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