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Issue 9, 2019
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Enantioselective synthesis of chiral heterocyclic biaryls via asymmetric Suzuki–Miyaura cross-coupling of 3-bromopyridine derivatives

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Abstract

A series of chiral heterocyclic biaryls with a pyridyl moiety were prepared in moderate to good yields with up to 92% ee via asymmetric Suzuki–Miyaura coupling. The chiral-bridged biphenyl monophosphine ligand L1 was found to be much more effective in the reaction enantioselection than its counterpart binaphthyl monophosphine ligands.

Graphical abstract: Enantioselective synthesis of chiral heterocyclic biaryls via asymmetric Suzuki–Miyaura cross-coupling of 3-bromopyridine derivatives

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Publication details

The article was received on 06 Dec 2018, accepted on 06 Feb 2019 and first published on 06 Feb 2019


Article type: Communication
DOI: 10.1039/C8OB03048K
Org. Biomol. Chem., 2019,17, 2351-2355

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    Enantioselective synthesis of chiral heterocyclic biaryls via asymmetric Suzuki–Miyaura cross-coupling of 3-bromopyridine derivatives

    W. Xia, Z. Zhang, Y. Li, X. Jiang, H. Liang, Y. Zhang, R. Cao and L. Qiu, Org. Biomol. Chem., 2019, 17, 2351
    DOI: 10.1039/C8OB03048K

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