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Issue 4, 2019
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Synthesis of cyano-substituted carbazoles via successive C–C/C–H cleavage

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Abstract

A highly efficient protocol for the synthesis of polysubstituted cyano carbazoles has been developed. This process is realized through the tandem reactions of Cs2CO3 promoted C–C σ-bond activation of α-cyano ketones followed by Fe-catalyzed selective C–H and/or C–C bond activations. Two of the sp2 C–H bonds are functionalized, and two of the C–C σ-bonds are cleaved involving a 1,2-acyl migration during the reaction process.

Graphical abstract: Synthesis of cyano-substituted carbazoles via successive C–C/C–H cleavage

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Publication details

The article was received on 05 Dec 2018, accepted on 03 Jan 2019 and first published on 04 Jan 2019


Article type: Paper
DOI: 10.1039/C8OB03031F
Org. Biomol. Chem., 2019,17, 958-965

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    Synthesis of cyano-substituted carbazoles via successive C–C/C–H cleavage

    Y. Yang, J. Huang, H. Tan, L. Kong, M. Wang, Y. Yuan and Y. Li, Org. Biomol. Chem., 2019, 17, 958
    DOI: 10.1039/C8OB03031F

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