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Issue 1, 2019
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Efficient synthesis and characterisation of the amyloid beta peptide, Aβ1–42, using a double linker system

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Abstract

The amyloidogenic Aβ42 peptide was efficiently prepared using a double linker system, markedly improving solubility and chromatographic peak resolution, thus enabling full characterisation using standard techniques. The tag was readily cleaved with sodium hydroxide and removed by aqueous extraction, affording Aβ42 in high purity and yield for biophysical characterisation studies.

Graphical abstract: Efficient synthesis and characterisation of the amyloid beta peptide, Aβ1–42, using a double linker system

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Article information


Submitted
23 Nov 2018
Accepted
26 Nov 2018
First published
26 Nov 2018

This article is Open Access

Org. Biomol. Chem., 2019,17, 30-34
Article type
Communication

Efficient synthesis and characterisation of the amyloid beta peptide, Aβ1–42, using a double linker system

J. K. Kasim, I. Kavianinia, J. Ng, P. W. R. Harris, N. P. Birch and M. A. Brimble, Org. Biomol. Chem., 2019, 17, 30
DOI: 10.1039/C8OB02929F

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