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Issue 2, 2019
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I2/TBHP-Mediated tandem cyclization and oxidation reaction: Facile access to 2-substituted thiazoles and benzothiazoles

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Abstract

The efficient synthesis of 2-substituted thiazoles and benzothiazoles has been accomplished employing readily available cysteine esters and 2-aminobenzenethiols as N and S sources. The reaction proceeds under an I2/TBHP system and involves a one-pot tandem cyclization and oxidation sequence. A diverse range of aldehydes is amenable for this transition-metal-free protocol, which provides an alternative method to rapidly access thiazole-containing molecules.

Graphical abstract: I2/TBHP-Mediated tandem cyclization and oxidation reaction: Facile access to 2-substituted thiazoles and benzothiazoles

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Publication details

The article was received on 13 Nov 2018, accepted on 09 Dec 2018 and first published on 10 Dec 2018


Article type: Communication
DOI: 10.1039/C8OB02826E
Org. Biomol. Chem., 2019,17, 252-256

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    I2/TBHP-Mediated tandem cyclization and oxidation reaction: Facile access to 2-substituted thiazoles and benzothiazoles

    L. Liu, C. Tan, R. Fan, Z. Wang, H. Du, K. Xu and J. Tan, Org. Biomol. Chem., 2019, 17, 252
    DOI: 10.1039/C8OB02826E

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