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Issue 7, 2019
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A fast-response and highly specific Si-Rhodamine probe for endogenous peroxynitrite detection in living cells

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Abstract

Peroxynitrite (ONOO) is involved in a variety of physiological and pathological processes. We designed and synthesized a fluorescent probe SiNH based on Si-rhodamine. The nanoprobe SiNH encapsulated within the amphiphilic copolymer exhibited fast response within 10 s, and it was highly specific for ONOO in aqueous solution. It is demonstrated that the nanoprobe SiNH is applicable for real-time tracing of endogenous ONOO in living cells.

Graphical abstract: A fast-response and highly specific Si-Rhodamine probe for endogenous peroxynitrite detection in living cells

  • This article is part of the themed collection: New Talent
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Supplementary files

Article information


Submitted
06 Jul 2018
Accepted
30 Jul 2018
First published
30 Jul 2018

Org. Biomol. Chem., 2019,17, 1875-1880
Article type
Paper

A fast-response and highly specific Si-Rhodamine probe for endogenous peroxynitrite detection in living cells

J. Tang, Q. Li, Z. Guo and W. Zhu, Org. Biomol. Chem., 2019, 17, 1875
DOI: 10.1039/C8OB01598H

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