Aldehydes can switch the chemoselectivity of electrophiles in protein labeling
We show that the chemoselectivity of an electrophile in protein labeling can be promiscuous. An aldehyde enables switching of chemoselectivity of an epoxide and a sulfonate ester along with an enhanced rate of reaction. The chemical technology renders single-site installation of diverse probes on a protein and delivers analytically pure tagged proteins.
- This article is part of the themed collections: Chemical biology in OBC, Celebrating the RAOBC symposium and Organic & Biomolecular Chemistry 2018 HOT article collection