Issue 48, 2018

Copper-catalyzed three-component synthesis of pyrimidines from amidines and alcohols

Abstract

An efficient copper-catalyzed one-pot three-component reaction of amidines, primary alcohols and secondary alcohols has been developed to synthesize multisubstituted pyrimidines. The significant merits of this method involve high atom efficiency, good functional group tolerance and operational simplicity.

Graphical abstract: Copper-catalyzed three-component synthesis of pyrimidines from amidines and alcohols

Supplementary files

Article information

Article type
Paper
Submitted
31 Oct 2018
Accepted
28 Nov 2018
First published
29 Nov 2018

Org. Biomol. Chem., 2018,16, 9487-9491

Copper-catalyzed three-component synthesis of pyrimidines from amidines and alcohols

T. Shi, F. Qin, Q. Li and W. Zhang, Org. Biomol. Chem., 2018, 16, 9487 DOI: 10.1039/C8OB02694G

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