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Issue 40, 2018
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Rapid synthesis of 3-amino isocoumarin derivatives from ynamides

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Abstract

A novel and efficient fast synthesis of 3-amino isocoumarins in good to excellent yields is reported. These interesting scaffolds can be obtained either in a single step from readily available ynamides or in a two-step sequence from the corresponding alkynyl bromide after C–N cross-coupling. This protocol, which only requires a Brønsted or Lewis acid as a promoter, offers an alternative approach toward synthesizing 3-substituted isocoumarins under smooth and fast conditions.

Graphical abstract: Rapid synthesis of 3-amino isocoumarin derivatives from ynamides

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Publication details

The article was received on 18 Sep 2018, accepted on 25 Sep 2018 and first published on 25 Sep 2018


Article type: Communication
DOI: 10.1039/C8OB02305K
Citation: Org. Biomol. Chem., 2018,16, 7351-7355
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    Rapid synthesis of 3-amino isocoumarin derivatives from ynamides

    L. Habert, P. Retailleau and I. Gillaizeau, Org. Biomol. Chem., 2018, 16, 7351
    DOI: 10.1039/C8OB02305K

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