Issue 39, 2018

Synthesis of stereochemically-biased spiropyrans by microwave-promoted, one-pot alkylation–condensation

Abstract

A microwave-assisted, two-step, one-pot synthesis of spiropyrans has been developed. This process was used to synthesise a range of sterically-congested spiropyrans from readily available precursors, employing environmentally benign solvents. The unusual substituent pattern possessed by these structures has been shown to influence the stereoselectivity of spiropyran ring-closure.

Graphical abstract: Synthesis of stereochemically-biased spiropyrans by microwave-promoted, one-pot alkylation–condensation

Supplementary files

Article information

Article type
Paper
Submitted
15 Aug 2018
Accepted
20 Sep 2018
First published
21 Sep 2018

Org. Biomol. Chem., 2018,16, 7245-7254

Synthesis of stereochemically-biased spiropyrans by microwave-promoted, one-pot alkylation–condensation

A. Perry, K. Davis and L. West, Org. Biomol. Chem., 2018, 16, 7245 DOI: 10.1039/C8OB01996G

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