Issue 39, 2018
From the journal:

Organic & Biomolecular Chemistry

Iron-catalysed carbene-transfer reactions of diazo acetonitrile†

Claire Empel, ORCID logo a   Katharina J. Hock ORCID logo a  and  Rene M. Koenigs ORCID logo *a  

* Corresponding authors

a RWTH Aachen University, Institute of Organic Chemistry, Landoltweg 1, D-52074 Aachen, Germany
E-mail: rene.koenigs@rwth-aachen.de

Abstract

A continuous-flow protocol for the synthesis of diazo acetonitrile was developed. It was further applied in iron-catalysed insertion reactions of diazo acetonitrile into N–H and S–H bonds to yield valuable α-substituted acetonitrile, including gram-scale synthesis.

Graphical abstract: Iron-catalysed carbene-transfer reactions of diazo acetonitrile

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Article information

DOI
https://doi.org/10.1039/C8OB01991F
Article type
Communication
Submitted
15 Aug 2018
Accepted
20 Sep 2018
First published
20 Sep 2018

Org. Biomol. Chem., 2018,16, 7129-7133

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Iron-catalysed carbene-transfer reactions of diazo acetonitrile

C. Empel, K. J. Hock and R. M. Koenigs, Org. Biomol. Chem., 2018, 16, 7129 DOI: 10.1039/C8OB01991F

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