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Issue 35, 2018
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Nickel catalyzed site selective C–H functionalization of α-aryl-thioamides

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Abstract

A catalytic site selective intramolecular C–S bond forming reaction is demonstrated for the first time. The C–H bond functionalization of α-aryl-thioacetanilides was efficiently catalyzed by 2 mol% NiBr2, resulting in valuable 2-aminobenzo[b]thiophenes in moderate to good yields. Furthermore, the selective sp2 C–H bond functionalization over sp3 is exemplified.

Graphical abstract: Nickel catalyzed site selective C–H functionalization of α-aryl-thioamides

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Supplementary files

Article information


Submitted
18 Jul 2018
Accepted
22 Aug 2018
First published
23 Aug 2018

Org. Biomol. Chem., 2018,16, 6405-6409
Article type
Communication

Nickel catalyzed site selective C–H functionalization of α-aryl-thioamides

D. Bandyopadhyay, A. Thirupathi, N. M. Dhage, N. Mohanta and S. Peruncheralathan, Org. Biomol. Chem., 2018, 16, 6405
DOI: 10.1039/C8OB01712C

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