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Issue 35, 2018
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Nickel catalyzed site selective C–H functionalization of α-aryl-thioamides

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Abstract

A catalytic site selective intramolecular C–S bond forming reaction is demonstrated for the first time. The C–H bond functionalization of α-aryl-thioacetanilides was efficiently catalyzed by 2 mol% NiBr2, resulting in valuable 2-aminobenzo[b]thiophenes in moderate to good yields. Furthermore, the selective sp2 C–H bond functionalization over sp3 is exemplified.

Graphical abstract: Nickel catalyzed site selective C–H functionalization of α-aryl-thioamides

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Publication details

The article was received on 18 Jul 2018, accepted on 22 Aug 2018 and first published on 23 Aug 2018


Article type: Communication
DOI: 10.1039/C8OB01712C
Citation: Org. Biomol. Chem., 2018,16, 6405-6409

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    Nickel catalyzed site selective C–H functionalization of α-aryl-thioamides

    D. Bandyopadhyay, A. Thirupathi, N. M. Dhage, N. Mohanta and S. Peruncheralathan, Org. Biomol. Chem., 2018, 16, 6405
    DOI: 10.1039/C8OB01712C

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