Issue 35, 2018

Radical alkylation of para-quinone methides with 4-substituted Hantzsch esters/nitriles via organic photoredox catalysis

Abstract

A novel photocatalytic protocol is herein described for the preparation of functionalized phenols via radical alkylation of para-quinone methides under transition-metal-free conditions. The reaction is external oxidant free and performed at ambient temperature upon visible light irradiation, allowing the access to various desired products in satisfactory yields. The readily available 4-alkyl-1,4-dihydropyridines serve as the effective alkyl radical precursors.

Graphical abstract: Radical alkylation of para-quinone methides with 4-substituted Hantzsch esters/nitriles via organic photoredox catalysis

Supplementary files

Article information

Article type
Communication
Submitted
12 Jul 2018
Accepted
18 Aug 2018
First published
20 Aug 2018

Org. Biomol. Chem., 2018,16, 6391-6394

Radical alkylation of para-quinone methides with 4-substituted Hantzsch esters/nitriles via organic photoredox catalysis

Q. Wu, Q. Min, G. Ao and F. Liu, Org. Biomol. Chem., 2018, 16, 6391 DOI: 10.1039/C8OB01641K

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