Issue 35, 2018

Synthesis and characterization of various 5′-dye-labeled ribonucleosides

Abstract

Hitherto unknown chromophoric nucleosides are reported. This novel set of visibly coloured dye-labeled 5′-nucleosides, including 1,2,4,5-tetrazine, dicyanomethylene-4H-pyran, benzophenoxazinone, 9,10-anthraquinone and azobenzene chromophores, were prepared mainly under Cu-catalyzed azide–alkyne cycloaddition (CuAAC). The design criteria are outlined. Several derivatives possess in supplement a fluorescence property. The absorption and fluorescence spectra of all coloured nucleosides were recorded to study their potential as visible-range probes. Such nucleodyes are of great interest for future competitive lateral flow test MIP-based strips.

Graphical abstract: Synthesis and characterization of various 5′-dye-labeled ribonucleosides

Supplementary files

Article information

Article type
Paper
Submitted
07 Jul 2018
Accepted
21 Aug 2018
First published
21 Aug 2018

Org. Biomol. Chem., 2018,16, 6552-6563

Synthesis and characterization of various 5′-dye-labeled ribonucleosides

C. De Schutter, V. Roy, P. Favetta, C. Pavageau, S. Maisonneuve, N. Bogliotti, J. Xie and L. A. Agrofoglio, Org. Biomol. Chem., 2018, 16, 6552 DOI: 10.1039/C8OB01606B

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