Issue 30, 2018

Transition-metal-free synthesis of polysubstituted pyrrole derivatives via cyclization of methyl isocyanoacetate with aurone analogues

Abstract

Presented herein is an unprecedented transition-metal-free cyclization of methyl isocyanoacetate with aurone analogues catalyzed by NaOH. Various 2,3,4-trisubstituted pyrroles were obtained in excellent yields (up to 99%). The high efficiency of this synthetic procedure, coupled with the operational simplicity and atom economy, makes it an attractive method for the synthesis of polysubstituted pyrroles.

Graphical abstract: Transition-metal-free synthesis of polysubstituted pyrrole derivatives via cyclization of methyl isocyanoacetate with aurone analogues

Supplementary files

Article information

Article type
Communication
Submitted
03 Jul 2018
Accepted
18 Jul 2018
First published
18 Jul 2018

Org. Biomol. Chem., 2018,16, 5422-5426

Transition-metal-free synthesis of polysubstituted pyrrole derivatives via cyclization of methyl isocyanoacetate with aurone analogues

Z. Wang, Y. He and P. Shao, Org. Biomol. Chem., 2018, 16, 5422 DOI: 10.1039/C8OB01558A

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