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Issue 38, 2018
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A novel synthesis of N-hydroxy-3-aroylindoles and 3-aroylindoles

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Abstract

A straightforward indole synthesis via annulation of C-nitrosoaromatics with conjugated terminal alkynones was realised achieving a simple, highly regioselective, atom- and step economical access to 3-aroylindoles in moderate to good yields. Further functionalizations of indole scaffolds were investigated and an easy way to JWH-018, a synthetic cannabinoid, was achieved.

Graphical abstract: A novel synthesis of N-hydroxy-3-aroylindoles and 3-aroylindoles

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Publication details

The article was received on 21 Jun 2018, accepted on 24 Jul 2018 and first published on 24 Jul 2018


Article type: Communication
DOI: 10.1039/C8OB01471J
Citation: Org. Biomol. Chem., 2018,16, 6853-6859

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    A novel synthesis of N-hydroxy-3-aroylindoles and 3-aroylindoles

    G. Ieronimo, G. Palmisano, A. Maspero, A. Marzorati, L. Scapinello, N. Masciocchi, G. Cravotto, A. Barge, M. Simonetti, K. L. Ameta, K. M. Nicholas and A. Penoni, Org. Biomol. Chem., 2018, 16, 6853
    DOI: 10.1039/C8OB01471J

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