Issue 33, 2018

Highly sulphated cellulose: a versatile, reusable and selective desilylating agent for deprotection of alcoholic TBDMS ethers

Abstract

A mild, efficient and rapid protocol was developed for the deprotection of alcoholic TBDMS ethers using a recyclable, eco-friendly highly sulphated cellulose sulphate acid catalyst in methanol. This acid catalyst selectively cleaves alcoholic TBDMS ethers in bis-TBDMS ethers containing both alcoholic and phenolic TBDMS ether moieties.

Graphical abstract: Highly sulphated cellulose: a versatile, reusable and selective desilylating agent for deprotection of alcoholic TBDMS ethers

Supplementary files

Article information

Article type
Paper
Submitted
18 Jun 2018
Accepted
03 Aug 2018
First published
06 Aug 2018

Org. Biomol. Chem., 2018,16, 6057-6062

Author version available

Highly sulphated cellulose: a versatile, reusable and selective desilylating agent for deprotection of alcoholic TBDMS ethers

S. S. Dachavaram, N. R. Penthala, J. L. Calahan, E. J. Munson and P. A. Crooks, Org. Biomol. Chem., 2018, 16, 6057 DOI: 10.1039/C8OB01438H

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