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Issue 35, 2018
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Pd-Catalyzed C(sp2)–H aminocarbonylation using the Langlois reagent as a carbonyl source

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Abstract

A Pd-catalyzed C(sp2)–H aminocarbonylation of aryl carboxamides assisted by an N,S-bidentate directing group was developed, in which cheap and stable sodium trifluoromethanesulfinate was first utilized as a carbonyl source. The reaction can be applicable to a wide range of carboxamides with good functional group tolerance and afford isoindole-1,3-diones in moderate to good yields.

Graphical abstract: Pd-Catalyzed C(sp2)–H aminocarbonylation using the Langlois reagent as a carbonyl source

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Publication details

The article was received on 15 Jun 2018, accepted on 15 Aug 2018 and first published on 16 Aug 2018


Article type: Paper
DOI: 10.1039/C8OB01421C
Citation: Org. Biomol. Chem., 2018,16, 6438-6442

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    Pd-Catalyzed C(sp2)–H aminocarbonylation using the Langlois reagent as a carbonyl source

    X. Li, L. Shi, X. Zhang and X. Zhang, Org. Biomol. Chem., 2018, 16, 6438
    DOI: 10.1039/C8OB01421C

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