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Issue 33, 2018
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Ruthenium-catalyzed synthesis of arylethyl 1,3,5-triazines from arylallyl alcohols and biguanides

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Abstract

An efficient ruthenium-catalyzed synthesis of alkyl-1,3,5-triazies from arylallyl alcohols and biguanides has been developed. The reaction occurred in moderate to good yields and tolerated heterocyclic or aryl allyl alcohols containing functionalities such as alkanes, ethers, and halogens. The reaction proceeds through a one-pot sequence of transfer hydrogenation and condensation steps.

Graphical abstract: Ruthenium-catalyzed synthesis of arylethyl 1,3,5-triazines from arylallyl alcohols and biguanides

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Article information


Submitted
13 Jun 2018
Accepted
06 Aug 2018
First published
07 Aug 2018

Org. Biomol. Chem., 2018,16, 6140-6145
Article type
Paper

Ruthenium-catalyzed synthesis of arylethyl 1,3,5-triazines from arylallyl alcohols and biguanides

M. Zeng, Z. P. Xie, D. Cui and C. Zhang, Org. Biomol. Chem., 2018, 16, 6140
DOI: 10.1039/C8OB01397G

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