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Issue 29, 2018
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TEMPO promoted direct multi-functionalization of terminal alkynes with 2-oxindoles/benzofuran-2(3H)-one

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Abstract

Highly selective and catalyst-free tandem multi-functionalization of terminal alkynes was developed with 2-oxindoles and benzo-furan-2(3H)-one using TEMPO both as a radical promoter and a trapping reagent. This work expands the scope of the radical-cascade addition/trapping process of alkynes for the effective construction of various β-oxyl carbonyls in moderate to good yields.

Graphical abstract: TEMPO promoted direct multi-functionalization of terminal alkynes with 2-oxindoles/benzofuran-2(3H)-one

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Publication details

The article was received on 11 Jun 2018, accepted on 30 Jun 2018 and first published on 02 Jul 2018


Article type: Communication
DOI: 10.1039/C8OB01380B
Citation: Org. Biomol. Chem., 2018,16, 5228-5231

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    TEMPO promoted direct multi-functionalization of terminal alkynes with 2-oxindoles/benzofuran-2(3H)-one

    Q. Liu, J. Liu, L. Cheng, D. Wang and L. Liu, Org. Biomol. Chem., 2018, 16, 5228
    DOI: 10.1039/C8OB01380B

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