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Issue 37, 2018
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Catalyst-free synthesis of α-thioacrylic acids via cascade thiolation and 1,4-aryl migration of aryl alkynoates at room temperature

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Abstract

A simple and facile catalyst-free method for the construction of α-thioacrylic acids has been developed from readily-available aryl alkynoates and thiols at room temperature. Various α-thioacrylic acids could be conveniently and efficiently obtained in moderate to good yields via cascade thiolation and 1,4-aryl migration of aryl alkynoates in the absence of any catalyst and additive.

Graphical abstract: Catalyst-free synthesis of α-thioacrylic acids via cascade thiolation and 1,4-aryl migration of aryl alkynoates at room temperature

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Supplementary files

Article information


Submitted
08 Jun 2018
Accepted
30 Aug 2018
First published
13 Sep 2018

Org. Biomol. Chem., 2018,16, 8379-8383
Article type
Paper

Catalyst-free synthesis of α-thioacrylic acids via cascade thiolation and 1,4-aryl migration of aryl alkynoates at room temperature

W. Wei, L. Wang, H. Yue, Y. Jiang and D. Yang, Org. Biomol. Chem., 2018, 16, 8379
DOI: 10.1039/C8OB01349G

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