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Issue 30, 2018
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C–H alkylation reactions of indoles mediated by Pd(II) and norbornene: applications and recent developments

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Abstract

The Catellani reaction enables an ortho-C–H activation based on oxidative addition of Pd(0) and an intermediary carbopalladation of norbornene. Among its variants, the recently developed C2-selective alkylation of indoles is particular as it employs Pd(II) as the source of palladium. This review describes the mechanistic background of this transformation. Applications in total synthesis and in the synthesis of biologically relevant molecules are illustrated and further developments of the method are discussed.

Graphical abstract: C–H alkylation reactions of indoles mediated by Pd(ii) and norbornene: applications and recent developments

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Publication details

The article was received on 02 May 2018, accepted on 04 Jul 2018 and first published on 04 Jul 2018


Article type: Review Article
DOI: 10.1039/C8OB01025K
Citation: Org. Biomol. Chem., 2018,16, 5376-5385

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    C–H alkylation reactions of indoles mediated by Pd(II) and norbornene: applications and recent developments

    M. Wegmann, M. Henkel and T. Bach, Org. Biomol. Chem., 2018, 16, 5376
    DOI: 10.1039/C8OB01025K

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