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Issue 21, 2018
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Copper-catalyzed remote oxidation of alcohols initiated by radical difluoroalkylation of alkenes: facile access to difluoroalkylated carbonyl compounds

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Abstract

A Cu-catalyzed oxidation of alcohols triggered by the radical difluoroalkylation of alkenes has been developed, providing facile access to a series of difluoroalkylated ketones or aldehydes in moderate to high yields. The concurrent realization of the catalytic oxidation of alcohols and difluoroalkylation of alkenes enables a highly efficient and attractive method for organic synthesis.

Graphical abstract: Copper-catalyzed remote oxidation of alcohols initiated by radical difluoroalkylation of alkenes: facile access to difluoroalkylated carbonyl compounds

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Article information


Submitted
16 Apr 2018
Accepted
02 May 2018
First published
03 May 2018

Org. Biomol. Chem., 2018,16, 3876-3880
Article type
Communication

Copper-catalyzed remote oxidation of alcohols initiated by radical difluoroalkylation of alkenes: facile access to difluoroalkylated carbonyl compounds

J. Zhang, W. Jin, C. Cheng and F. Luo, Org. Biomol. Chem., 2018, 16, 3876
DOI: 10.1039/C8OB00889B

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