Issue 21, 2018

Gold-catalyzed C5-alkylation of indolines and sequential oxidative aromatization: access to C5-functionalized indoles

Abstract

A novel protocol for the synthesis of C5-alkylated indole derivatives via a gold-catalyzed reaction of indolines with diazo compounds and subsequent oxidative aromatization has been developed. C–H bond functionalization selectively occurs at the C5-position of indolines without a directing group. The experimental operation is simple and the whole process can be manipulated in one-pot.

Graphical abstract: Gold-catalyzed C5-alkylation of indolines and sequential oxidative aromatization: access to C5-functionalized indoles

Supplementary files

Article information

Article type
Communication
Submitted
08 Apr 2018
Accepted
02 May 2018
First published
02 May 2018

Org. Biomol. Chem., 2018,16, 3889-3892

Gold-catalyzed C5-alkylation of indolines and sequential oxidative aromatization: access to C5-functionalized indoles

W. Zhang, G. Xu, L. Qiu and J. Sun, Org. Biomol. Chem., 2018, 16, 3889 DOI: 10.1039/C8OB00826D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements