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Issue 20, 2018
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Belamchinenin A, an unprecedented tricyclic-fused triterpenoid with cytotoxicity from Belamcanda chinensis

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Abstract

Belamchinenin A (1), an unprecedented 6/5/6-fused tricyclic triterpenoid with a novel carbon skeleton, has been isolated from the rhizomes of Belamcanda chinensis. Compound 1 features a half-caged tricyclic nucleus with a flexible geranyl side chain. Its structure was determined by the interpretation of spectroscopic data. The absolute configuration of tricyclic nucleus system of 1 was unequivocally assigned by ECD calculation. Geometries optimization indicated that the tricyclic nucleus system is rigid. Compound 1 showed cytotoxic activities against five cells with IC50 values from 2.29 to 4.47 μM.

Graphical abstract: Belamchinenin A, an unprecedented tricyclic-fused triterpenoid with cytotoxicity from Belamcanda chinensis

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Publication details

The article was received on 04 Apr 2018, accepted on 27 Apr 2018 and first published on 02 May 2018


Article type: Paper
DOI: 10.1039/C8OB00789F
Org. Biomol. Chem., 2018,16, 3754-3759

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    Belamchinenin A, an unprecedented tricyclic-fused triterpenoid with cytotoxicity from Belamcanda chinensis

    G. Ni, J. Li and D. Yu, Org. Biomol. Chem., 2018, 16, 3754
    DOI: 10.1039/C8OB00789F

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