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Issue 16, 2018
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Ruthenium(ii)-catalyzed remote C–H addition of 8 aminoquinoline amide to activated aldehyde

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Abstract

Ruthenium(II)-catalyzed regioselective remote C–H addition of 8-aminoquinoline amides at C-5 position to ethyl glyoxalate and 2,2,2-trifluoroacetaldehyde have been developed. The transformation affords C-5 functionalized quinolines in moderate to good yields. This method is applicable to various aryl, heteroaryl as well as aliphatic carboxamides. Experimental results suggest that the reaction very likely proceeds through an ionic pathway.

Graphical abstract: Ruthenium(ii)-catalyzed remote C–H addition of 8 aminoquinoline amide to activated aldehyde

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Supplementary files

Article information


Submitted
03 Mar 2018
Accepted
24 Mar 2018
First published
26 Mar 2018

Org. Biomol. Chem., 2018,16, 2846-2850
Article type
Communication

Ruthenium(II)-catalyzed remote C–H addition of 8 aminoquinoline amide to activated aldehyde

S. Mondal and A. Hajra, Org. Biomol. Chem., 2018, 16, 2846
DOI: 10.1039/C8OB00537K

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