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Issue 17, 2018
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Straightforward synthesis of enantiomerically pure 1,2,3-triazoles derived from amino esters

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Abstract

A practical and straightforward approach that enables, for the first time, the synthesis of enantiomerically pure 1,4,5-trisubstituted, 1,5-disubstituted, and fused 1,2,3-triazole derivatives has been developed. The synthesis employs enantiomerically pure amino esters derived from amino acids and commercially available ketones under metal-free conditions.

Graphical abstract: Straightforward synthesis of enantiomerically pure 1,2,3-triazoles derived from amino esters

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Publication details

The article was received on 02 Mar 2018, accepted on 03 Apr 2018 and first published on 03 Apr 2018


Article type: Paper
DOI: 10.1039/C8OB00533H
Org. Biomol. Chem., 2018,16, 3168-3176

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    Straightforward synthesis of enantiomerically pure 1,2,3-triazoles derived from amino esters

    G. Silveira-Dorta, S. Jana, L. Borkova, J. Thomas and W. Dehaen, Org. Biomol. Chem., 2018, 16, 3168
    DOI: 10.1039/C8OB00533H

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