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Issue 15, 2018
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Copper nitrate: a privileged reagent for organic synthesis

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Copper has been explored as an ideal candidate for replacing noble metals in organic synthesis, especially for practical large scale preparation. Recent decades have witnessed the renaissance and improvement of copper-catalyzed and copper-mediated organic reactions. Copper nitrate is a common inorganic copper salt which has been proved to be a ubiquitous reactant in organic synthesis due to its commercial availability, stability, inexpensiveness and environmentally benign nature. Copper nitrate could be used as a nitration reagent, oxidant, catalyst or promoter, and Lewis acid as well. Remarkably, great attention has been devoted to the efficient transformation of copper nitrate into functionalized or complicated compounds through various reaction types including cyclization, C–H activation, difunctionalization, nitration, rearrangement and asymmetric synthesis with chiral ligands. Further modification of copper nitrate, such as solid-supported copper nitrate or copper nitrate complexes, extends its applications in organic synthesis. The present review highlights recent advances of copper nitrate in organic synthesis, along with the mechanisms.

Graphical abstract: Copper nitrate: a privileged reagent for organic synthesis

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Article information

08 Feb 2018
12 Mar 2018
First published
14 Mar 2018

Org. Biomol. Chem., 2018,16, 2602-2618
Article type
Review Article

Copper nitrate: a privileged reagent for organic synthesis

M. Gao, R. Ye, W. Shen and B. Xu, Org. Biomol. Chem., 2018, 16, 2602
DOI: 10.1039/C8OB00332G

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