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Issue 13, 2018
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Stereospecific radiosynthesis of 3-fluoro amino acids: access to enantiomerically pure radioligands for positron emission tomography

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Abstract

A variety of substituted non-racemic aziridine-2-carboxylates equivalent to amino acids were prepared and subjected to ring opening reaction by [18F/19F]fluoride. The regio and stereospecific ring opening depends on the substituents on the nitrogen as well as both the carbons of aziridines. The applicability of the methods to afford access to 3-[18F/19F]fluoro amino acids are illustrated.

Graphical abstract: Stereospecific radiosynthesis of 3-fluoro amino acids: access to enantiomerically pure radioligands for positron emission tomography

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Publication details

The article was received on 22 Jan 2018, accepted on 19 Feb 2018 and first published on 15 Mar 2018


Article type: Communication
DOI: 10.1039/C8OB00184G
Org. Biomol. Chem., 2018,16, 2219-2224

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    Stereospecific radiosynthesis of 3-fluoro amino acids: access to enantiomerically pure radioligands for positron emission tomography

    S. R. Alluri and P. J. Riss, Org. Biomol. Chem., 2018, 16, 2219
    DOI: 10.1039/C8OB00184G

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