In vivo and in vitro identification of Z-BOX C – a new bilirubin oxidation end product

Marcel Ritter; Sandesh Neupane; Raphael A. Seidel; Christoph Steinbeck; Georg Pohnert

doi:10.1039/C8OB00164B

In vivo and in vitro identification of Z-BOX C – a new bilirubin oxidation end product

Marcel Ritter,^a Sandesh Neupane,^a Raphael A. Seidel,^a^b Christoph Steinbeck^a and Georg Pohnert*^a^c

Author affiliations

* Corresponding authors

^a Institute of Inorganic and Analytical Chemistry, Friedrich Schiller University, Lessingstrasse 8, D-07743 Jena, Germany
E-mail: Georg.Pohnert@uni-jena.de

^b Department of Anesthesiology and Intensive Care Medicine/Center for Sepsis Control and Care, Jena University Hospital, Am Klinikum 1, D-07747 Jena, Germany

^c Max-Planck-Institute for Chemical Ecology, Beutenberg Campus, Hans-Knöll-Str. 8, D-07745 Jena, Germany

Abstract

A new bilirubin oxidation end product (BOX) was isolated and characterized. The formation of the so-called Z-BOX C proceeds from bilirubin via propentdyopents as intermediates. This BOX was detected in pathological human bile samples using liquid chromatography/mass spectrometry and has potential relevance for liver dysfunction and cerebral vasospasms.

This article is part of the themed collections: Chemical biology in OBC and Organic & Biomolecular Chemistry 2018 HOT article collection

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Publication details

The article was received on 19 Jan 2018, accepted on 01 Mar 2018 and first published on 01 Mar 2018

Article type: Communication

DOI: 10.1039/C8OB00164B

Citation: Org. Biomol. Chem., 2018,16, 3553-3555

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In vivo and in vitro identification of Z-BOX C – a new bilirubin oxidation end product

M. Ritter, S. Neupane, R. A. Seidel, C. Steinbeck and G. Pohnert, Org. Biomol. Chem., 2018, 16, 3553
DOI: 10.1039/C8OB00164B
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Organic & Biomolecular Chemistry

In vivo and in vitro identification of Z-BOX C – a new bilirubin oxidation end product

Abstract

Supplementary files

Publication details

In vivo and in vitro identification of Z-BOX C – a new bilirubin oxidation end product

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